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Ten patients with relapsing-remitting multiple sclerosis were treated with intravenous immuno globulin,0.4 g/kg per day for 5 consecutive days,and then with additional booster doses of immune globulin of 0.4 g/kg,once every 2 months,for the next 12 months.Ten untreated aptients with relapsing-remitting multiple sclerosis who were matched with the study patients for age,disease duration,and number of attacks per year served as controls.Immune globulin teratment was well tolerated,with no side effects.The exacerbation rate decreased from 3.7=/-1.2 exacerbations per year before teratment to 1.0=/-0.7 exacerbations per year during the treatment in the immune globulin-treated patients,while it remained unaltered in the contrls.The posttreatment Kurtzke Expanded Disability Status Scale score decreased from a mean of 4.45 to 4.15,whereas in controls it increased from 3.55 to 3.75.The results suggest that immune globulin suppresses the ongoing pathologic process in multiple sclerosis and may be a promising treatment to prevent disease exacerbations. |
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gammaglobulin therapy,intravenous
multiple sclerosis
multiple sclerosis,relapsing
multiple sclerosis,treatment of
treatment of neurologic disorder
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